THIENOPYRIDINES: PLATELET ADP RECEPTOR ANTAGONIST
نویسندگان
چکیده
منابع مشابه
Anti-platelet therapy: ADP receptor antagonists
The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided that there are no adverse effects on haemostasis. Here we describe the ADP receptor antagonists th...
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Platelet activation plays an essential role in thrombosis. ADP-induced platelet aggregation is mediated by two distinct G protein-coupled ADP receptors, Gq-linked P2Y(1), and Gi-linked P2T(AC), which has not been cloned. The cDNA encoding a novel G protein-coupled receptor, termed HORK3, was isolated. The HORK3 gene and P2Y(1) gene were mapped to chromosome 3q21-q25. HORK3, when transfected in ...
متن کاملACCELERATED COMMUNICATION Molecular Cloning of the Platelet P2TAC ADP Receptor: Pharmacological Comparison with Another ADP Receptor, the P2Y1 Receptor
Platelet activation plays an essential role in thrombosis. ADPinduced platelet aggregation is mediated by two distinct G protein-coupled ADP receptors, Gq-linked P2Y1, and Gi-linked P2TAC, which has not been cloned. The cDNA encoding a novel G protein-coupled receptor, termed HORK3, was isolated. The HORK3 gene and P2Y1 gene were mapped to chromosome 3q21-q25. HORK3, when transfected in the rat...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2011
ISSN: 2250-1177
DOI: 10.22270/jddt.v1i1.7